Ciprofloxacine teva était un médicament qui était mis à disposition dans le milieu hospitalier à base de Ciprofloxacine mg. Traitement ou prophylaxie des infections chez les patients neutropéniques. Pour ce type d'infectio n s, la ciprofloxac i ne doit être ass o ci é e à d'autr e s a g ents anti b ac t érie n s a p pro p riés. Les d o nn é es s u r l ' effic a c i té de l a ciprofloxaci n e d ans le trait e ment d e s i nfectio n s p o st-opératoires i ntra- abdom i nal e s sont limité e s. L'utilisati o n d e la ciproflo x aci n e ch e z l ' enfant et l'ado l esc e nt doit suivre les reco m ma n dat i ons officiel le s en vigueur.
Purpose: This study aimed to characterize pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing scheme. Methods: Children treated with ciprofloxacin were included. Pharmacokinetics were described using non-linear mixed-effect modelling and validated with an external dataset. Results: A total of children concentrations were included. A two-compartment model with first-order absorption and elimination best described the data. An allometric model was used to describe bodyweight BW influence, and effects of estimated glomerular filtration rate eGFR and age were significant on ciprofloxacin clearance.


